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The pivotal efficacy studies recruited only patients with motor fluctuations. Because these events are reported voluntarily from a population of unknown size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Before taking this medicine You should not use Actemra if you are allergic to tocilizumab artigo. Psychosocial Issues High-dose chemotherapy with stem cell rescue can place physical, psychological, emotional, and financial stresses on patients and their families.